ASPEX is a set of programs for analysis of affected sibling pair data
for discrete traits. There are five main analysis programs:
sib_ibd, sib_phase, sib_map,
sib_tdt, and sib_kin.
sib_ibd performs exclusion mapping for data sets
with typed parents, and makes no inferences about missing data.
sib_phase performs exclusion mapping using allele
frequencies to reconstruct missing information, and is tailored
for data sets with missing parents, but additional typed children
that can be used to reconstruct and phase the parents.
sib_map is for multipoint marker distance estimation
from sib pair data.
sib_tdt is for transmission disequilibrium testing.
sib_kin is for verifying the degree of relatedness
of individuals within a family.
The source code is distributed under the GNU Public License. ASPEX is written in ANSI C and also requires the TCL toolkit and Perl. It is known to compile on Linux, Solaris, SunOS, and OSF-1.
Publications using ASPEX should include the citation: