ASPEX is a set of programs for analysis of affected sibling pair data
for discrete traits. There are five main analysis programs:
sib_ibdperforms exclusion mapping for data sets with typed parents, and makes no inferences about missing data.
sib_phaseperforms exclusion mapping using allele frequencies to reconstruct missing information, and is tailored for data sets with missing parents, but additional typed children that can be used to reconstruct and phase the parents.
sib_mapis for multipoint marker distance estimation from sib pair data.
sib_tdtis for transmission disequilibrium testing.
sib_kinis for verifying the degree of relatedness of individuals within a family.
The source code is distributed under the GNU Public License. ASPEX is written in ANSI C and also requires the TCL toolkit and Perl. It is known to compile on Linux, Solaris, SunOS, and OSF-1.
Publications using ASPEX should include the citation: